标题： 连接波动介导的多相场上皮单层流体化 显示英文标题

标题： Junctional-Fluctuation-Mediated Fluidisation of Multi-Phase Field Epithelial Monolayers

摘要： 我们分析了一个多相场模型，用于具有相邻细胞之间成对粘附的上皮单层，这些粘附遵循奥恩斯坦-乌伦贝克过程，代表了连接分子马达的随机周转。 这些连接粘附中的波动导致组织中的重排，使其液化并产生扩散的细胞运动。 类似的连接波动在顶点模型文献中已被证明是非常有用的工具，我们希望它们对多相场模型方法同样有帮助。 此外，我们观察到细胞的有效扩散系数随波动持续时间呈非单调变化，证实了之前在顶点模型中观察到的结果。 显示英文摘要

摘要： We analyse a multi-phase field model for an epithelial monolayer with pairwise adhesions between neighbouring cells following an Ornstein-Uhlenbeck process, representing the stochastic turnover of junctional molecular motors. These fluctuations in junctional adhesion result in rearrangements in the tissue, fluidising it and producing diffusive cell motion. Similar junctional fluctuations have proven a very useful tool in the vertex model literature, and we hope they will be equally helpful to the multi-phase field model approach. Moreover, we observe that the cells' effective diffusion coefficient depends non-monotonically on the persistence time of the fluctuations, confirming results previously observed in the vertex model.