标题： 一种使用扩散映射研究创伤性脑损伤丘脑连接性的纤维追踪分析框架 显示英文标题

标题： A Tractography Analysis Framework Using Diffusion Maps to Study Thalamic Connectivity in Traumatic Brain Injury

摘要： 创伤性脑损伤（TBI）破坏了丘脑皮层连接，导致认知障碍和创伤后癫痫（PTE）。 本研究提出了一种基于纤维追踪的框架，利用扩散图来捕捉丘脑白质路径的微结构和组织变化。 通过分析个体流线特征，我们发现了扩散图嵌入与功能结果（GOSE评分）之间的显著关联，突出了可能的损伤严重程度和恢复轨迹生物标志物。 我们的研究结果表明，白质纤维的细粒度几何特征可能为TBI相关的改变提供更敏感的标记。 显示英文摘要

摘要： Traumatic brain injury (TBI) disrupts thalamocortical connectivity, contributing to cognitive impairment and post-traumatic epilepsy (PTE). This study presents a novel tractography-based framework that leverages diffusion maps to capture microstructural and organizational changes in thalamic white matter pathways. By analyzing individual streamline characteristics, we identified significant associations between diffusion map embeddings and functional outcomes (GOSE scores), highlighting potential biomarkers for injury severity and recovery trajectories. Our findings suggest that fine-grained geometric features of white matter tracts may provide a more sensitive marker for TBI-related alterations.