标题： 软骨中辐射增强扩散作为骨关节炎及相关疾病放射治疗的物理机制 显示英文标题

标题： Radiation enhanced diffusion in cartilages as a physical mechanism underlying radiation treatments of osteoarthritis and related disorders

摘要： 关节软骨的退化可能导致骨关节炎（OA），影响大约10%的美国人口，并导致显著的住院费用。 虽然观察结果显示低剂量辐射治疗（LDRT）对大多数OA患者有改善作用，但其潜在机制尚不明确。 在这里，我们展示了辐射增强扩散（RED）如何促进软骨中的分子运输，从而促进软骨自我修复，为观察到的LDRT对OA的积极效果提供了一种机制。 除了对RED的定量估计外，我们还预测了电荷积累的相关现象，这允许LDRT方案促进以正或负分子物种为主的理想分子运输类型。 我们的分析呼吁进一步的实验验证和以治愈而非缓解为目的的临床试验。 除了OA应用外，我们开发的方法对于处理关节软骨损伤或退化的运动医学也有用。 显示英文摘要

摘要： Degradation of joint cartilages can result in osteoarthritis (OA) affecting about 10\% of the US population and responsible for significant hospitalization costs. While observations show that low dose radiation treatments (LDRT) bring improvements for a majority of OA patients, the underlying mechanism is not sufficiently understood. Here, we show how the radiation enhanced diffusion (RED) can boost the molecular transport in cartilages promoting cartilage self-healing rendering a mechanism for the observed positive LDRT effects on OA. Along with quantitative estimates for RED, we predict a related phenomenon of the electric charge build up that allows LDRT schedules promoting desirable types of molecular transports dominated by either positive or negative molecular species. Our analyses call upon further experimental verifications and clinical trials with curative rather than palliative intent. In addition to OA applications, our developed approaches can be useful for sports medicine dealing with damage or degeneration of the articular cartilages.