标题： 电场对脂质膜的影响 显示英文标题

标题： The effect of electric fields on lipid membranes

摘要： 与现有的理论模型相反，实验证据表明，电穿孔（在外加电场下膜缺陷的形成）开始出现在细胞可能经常经历的跨膜电压范围内，有趣的是，就在涉及神经信号传递的跨膜电压范围之上。 理解电场-脂质膜相互作用的基本原理似乎具有重要的生物学意义。 本文提出了一种方法，以利用DLVO理论来理解电穿孔的理论方面，这在电穿孔的背景下尚未被认可。 此外，强调了双层反离子和膜脂分子在斯特恩层上的色散相互作用（具有量子性质）。 这些力的方向使得它们压缩膜。 与此相关的理论是薄膜理论。 其论点是外部电场破坏了脂质膜两侧的排斥压力的对称性，导致只有少数脂质分子突出。 这在纳米尺度上破坏了膜的稳定性，并使其对离子可穿透。 基于这些论点得出的估计与电穿孔实验和现有的数值模拟一致。 显示英文摘要

摘要： Contrary to existing theoretical models, experimental evidence points out that electroporation (membrane defect formation under external electric fields) starts to occur within the range of transmembrane voltages that cells may routinely experience, curiously, just above the range of transmembrane voltages involved in neural signal transmission. Understanding the underlying principles of electric fields-lipid membrane interactions seems to carry a great biological importance. An argument is presented toward understanding the theoretical aspects of electroporation by using the DLVO theory, which has not been recognized previously in the context of electroporation. Further, the dispersion interactions (with its quantum nature), of the double layer counterions and membrane lipid molecules over the Stern layer are emphasized. The sign of these forces is such that they compress the membrane. A parallel is drawn to the theory of thin films. The argument is that the external electric field breaks the symmetry of the disjoining pressures on both sides of a lipid membrane, resulting in a protrusion of only few lipid molecules. That compromises the membrane stability on a nanoscale and makes it traversable to ions. The presented estimate based on these arguments is consistent to electroporation experiments and existing numerical simulations.