标题： 一种解决门控悖论的方法 显示英文标题

标题： A Solution to the Gating Paradox

摘要： 我们引入了一个马尔可夫模型来描述膜通道的门控。 该模型提供了一种可能的解决方案，即所谓的门控电流悖论，也就是描述动力学电压依赖性的钟形曲线比描述激活电压依赖性的S型曲线更宽，并且相对于后者有所偏移。 该模型还预测了这种偏移的一些温度依赖性，但目前尚未进行实验验证。 显示英文摘要

摘要： We introduce a Markov model for the gating of membrane channels. The model features a possible solution to the so-called gating current paradox, namely that the bell-shaped curve that describes the voltage dependence of the kinetics is broader than expected from, and shifted relative to, the sigmoidal curve that describes the voltage dependence of the activation. The model also predicts some temperature dependence of this shift, but presence of the latter has not been tested experimentally so far.