标题： 细胞的递归生成与可进化性：催化反应网络方法 显示英文标题

标题： On Recursive Production and Evolvabilty of Cells: Catalytic Reaction Network Approach

摘要： 为了揭示细胞从化学反应动力学层面的逻辑，我们需要明确一组化学物质如何自主地产生所需的化学物质，而无需假设特定的外部控制机制。 细胞由大量相互催化的化学物质组成。 通常，每种分子的数量并不是很大，因此每种分子的数量波动可能较大。 在如此多样性和大波动之中，细胞如何实现递归生产？ 另一方面，细胞可以在更长的时间跨度内改变其状态，以进化为不同的类型。 繁殖和进化如何兼容？ 我们基于几个催化反应网络的模型研究来回答这些问题。 在本文综述中，我们首先提出关于细胞递归性和可进化性的基本问题，然后陈述我们研究的立场，即所谓的“构造生物学”。 基于这一立场，我们提出了将细胞建模为化学反应网络的一般策略。 显示英文摘要

摘要： To unveil the logic of cell from a level of chemical reaction dynamics, we need to clarify how ensemble of chemicals can autonomously produce the set of chemical, without assuming a specific external control echanism. A cell consists of a huge number of chemical species that catalyze each other. Often the number of each molecule species is not so large, and accordingly the number fluctuations in each molecule speciescan be large. In the amidst of such diversity and large fluctuations, how can a cell make recursive production? On the other hand, a cell can change its state to evolve to a different type over a longer time span. How are reproduction and evolution compatible? We address these questions, based on several model studies with catalytic reaction network. In the present survey paper, we first formulate basic questions on the recursiveness and evolvability of a cell, and then state the standpoint of our research to answer the questions, that is termed as 'constructive biology'. Based on this standpoint, we present general strategy of modeling a cell as a chemical reaction network.