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Quantitative Biology > Quantitative Methods

arXiv:2509.02594 (q-bio)
[Submitted on 29 Aug 2025 ]

Title: OpenAIs HealthBench in Action: Evaluating an LLM-Based Medical Assistant on Realistic Clinical Queries

Title: OpenAI的HealthBench实战:在真实临床查询上评估基于大模型的医疗助手

Authors:Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stake clincal scenarios. Traditional evaluations are often limited to multiple-choice questions that fail to capture essential competencies such as contextual reasoning, awareness and uncertainty handling etc. To address these limitations, we evaluate our agentic, RAG-based clinical support assistant, DR.INFO, using HealthBench, a rubric-driven benchmark composed of open-ended, expert-annotated health conversations. On the Hard subset of 1,000 challenging examples, DR.INFO achieves a HealthBench score of 0.51, substantially outperforming leading frontier LLMs (GPT-5, o3, Grok 3, GPT-4, Gemini 2.5, etc.) across all behavioral axes (accuracy, completeness, instruction following, etc.). In a separate 100-sample evaluation against similar agentic RAG assistants (OpenEvidence, Pathway.md), it maintains a performance lead with a health-bench score of 0.54. These results highlight DR.INFOs strengths in communication, instruction following, and accuracy, while also revealing areas for improvement in context awareness and completeness of a response. Overall, the findings underscore the utility of behavior-level, rubric-based evaluation for building a reliable and trustworthy AI-enabled clinical support assistant.
Abstract: 评估大型语言模型(LLMs)在生成高质量、准确且情境意识强的临床问题答案方面的能力,需要超越传统基准测试,以评估这些系统在复杂、高风险的临床场景中的表现。 传统的评估通常仅限于选择题,这无法捕捉到上下文推理、意识和不确定性处理等关键能力。 为解决这些局限性,我们使用HealthBench,一个由评分标准驱动的基准测试,该测试由开放式、专家标注的健康对话组成,来评估我们的代理型、基于RAG的临床支持助手DR.INFO。 在1000个具有挑战性的示例的Hard子集上,DR.INFO获得了0.51的HealthBench分数,显著优于领先的前沿LLMs(GPT-5、o3、Grok 3、GPT-4、Gemini 2.5等),在所有行为轴(准确性、完整性、指令遵循等)上均表现出色。 在与类似的代理型RAG助手(OpenEvidence、Pathway.md)进行的单独100样本评估中,它保持了性能领先,HealthBench得分为0.54。 这些结果突显了DR.INFO在沟通、指令遵循和准确性方面的优势,同时也揭示了在情境意识和回答完整性方面的改进空间。 总体而言,这些发现强调了行为级别、基于评分标准的评估在构建可靠且值得信赖的AI支持的临床助手方面的实用性。
Comments: 13 pages, two graphs
Subjects: Quantitative Methods (q-bio.QM) ; Artificial Intelligence (cs.AI); Emerging Technologies (cs.ET); Information Retrieval (cs.IR)
Cite as: arXiv:2509.02594 [q-bio.QM]
  (or arXiv:2509.02594v1 [q-bio.QM] for this version)
  https://doi.org/10.48550/arXiv.2509.02594
arXiv-issued DOI via DataCite

Submission history

From: Valentine Emmanuel Gnanapragasam VmeG [view email]
[v1] Fri, 29 Aug 2025 09:51:41 UTC (917 KB)
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