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Quantitative Biology > Quantitative Methods

arXiv:2509.06192 (q-bio)
[Submitted on 7 Sep 2025 ]

Title: Hybrid restricted master problem for Boolean matrix factorisation

Title: 布尔矩阵分解的混合受限主问题

Authors:Ellen Visscher, Michael Forbes, Christopher Yau
Abstract: We present bfact, a Python package for performing accurate low-rank Boolean matrix factorisation (BMF). bfact uses a hybrid combinatorial optimisation approach based on a priori candidate factors generated from clustering algorithms. It selects the best disjoint factors before performing either a second combinatorial or heuristic algorithm to recover the BMF. We show that bfact does particularly well at estimating the true rank of matrices in simulated settings. In real benchmarks, using a collation of single-cell RNA-sequencing datasets from the Human Lung Cell Atlas, we show that bfact achieves strong signal recovery, with a much lower rank.
Abstract: 我们提出bfact,一个用于执行精确低秩布尔矩阵分解(BMF)的Python包。 bfact使用一种混合组合优化方法,该方法基于从聚类算法生成的先验候选因子。 它在执行第二次组合或启发式算法以恢复BMF之前选择最佳不相交因子。 我们表明,bfact在模拟设置中特别擅长估计矩阵的真实秩。 在真实基准测试中,使用来自人类肺部细胞图谱的单细胞RNA测序数据集的汇总数据,我们表明bfact实现了强大的信号恢复,并且具有更低的秩。
Subjects: Quantitative Methods (q-bio.QM)
Cite as: arXiv:2509.06192 [q-bio.QM]
  (or arXiv:2509.06192v1 [q-bio.QM] for this version)
  https://doi.org/10.48550/arXiv.2509.06192
arXiv-issued DOI via DataCite

Submission history

From: Ellen Visscher [view email]
[v1] Sun, 7 Sep 2025 20:03:10 UTC (8,423 KB)
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