Quantitative Biology > Quantitative Methods
[Submitted on 28 Sep 2025
]
Title: 13CFLUX - Third-generation high-performance engine for isotopically (non)stationary 13C metabolic flux analysis
Title: 13CFLUX - 第三代用于同位素（非）稳态13C代谢通量分析的高性能引擎
Abstract: 13C-based metabolic flux analysis (13C-MFA) is a cornerstone of quantitative systems biology, yet its increasing data complexity and methodological diversity place high demands on simulation software. We introduce 13CFLUX(v3), a third-generation simulation platform that combines a high-performance C++ engine with a convenient Python interface. The software delivers substantial performance gains across isotopically stationary and nonstationary analysis workflows, while remaining flexible to accommodate diverse labeling strategies and analytical platforms. Its open-source availability facilitates seamless integration into computational ecosystems and community-driven extension. By supporting multi-experiment integration, multi-tracer studies, and advanced statistical inference such as Bayesian analysis, 13CFLUX provides a robust and extensible framework for modern fluxomics research.
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