标题： 麻醉气体一氧化二氮在溶液中的振动红外寿命 显示英文标题

标题： Vibrational Infrared Lifetime of the Anesthetic nitrous oxide gas in solution

摘要： 麻醉气体一氧化二氮（N$_2$O）在辛醇和橄榄油中溶解的不对称基频伸缩振动 2218 cm$^{-1}$的寿命被报道。 这些溶剂是常用于评估麻醉效力的模型系统。 皮秒时间尺度的分子动力学模拟表明，蛋白质动力学或膜动力学在麻醉作用的分子机制中起作用。 具有 100 fs 时间分辨率的超快红外光谱是探测此类时间尺度上麻醉分子动力学的理想工具。 在振动带峰值处的泵浦-探测研究在橄榄油中得到 $55 \pm 1$ ps 的寿命，在辛醇中得到 $52 \pm 1 ps$ 的寿命。 寿命的相似性表明，麻醉剂的能量弛豫主要由环境的疏水性质决定，这与麻醉作用的模型一致。 结果表明，一氧化二氮是使用非线性红外光谱探测麻醉剂-溶剂相互作用的良好模型系统。 显示英文摘要

摘要： The lifetime of the asymmetric fundamental stretching 2218 cm$^{-1}$ vibration of the anesthetic gas nitrous oxide (N$_2$O) dissolved in octanol and olive oil is reported. These solvents are model systems commonly used to assess anesthetic potency. Picosecond time-scale molecular dynamics simulations have suggested that protein dynamics or membrane dynamics play a role in the molecular mechanism of anesthetic action. Ultrafast infrared spectroscopy with 100 fs time resolution is an ideal tool to probe dynamics of anesthetic molecules on such timescales. Pump-probe studies at the peak of the vibrational band yield a lifetime of $55 \pm 1$ ps in olive oil and $52 \pm 1 ps$ in octanol. The similarity of lifetimes suggests that energy relaxation of the anesthetic is determined primarily by the hydrophobic nature of the environment, consistent with models of anesthetic action. The results show that nitrous oxide is a good model system for probing anesthetic-solvent interactions using nonlinear infrared spectroscopy.