标题： 机械敏感通道自组织簇的集体响应 显示英文标题

标题： Collective response of self-organised clusters of mechanosensitive channels

摘要： 机械敏感通道是由膜张力激活的离子通道。 我们研究细菌机械敏感通道的空间分布对激活（门控）的影响。 基于弹性短程相互作用，我们将这一物理过程映射到一个类似伊辛模型的模型，这使我们能够预测通道的聚集及其对门控的影响。 我们得出结论，通道的聚集及其相互作用导致了全局协同门控行为，这可能对细胞产生重大影响。 显示英文摘要

摘要： Mechanosensitive channels are ion channels activated by membrane tension. We investigate the influence of bacterial mechanosensitive channels spatial distribution on activation (gating). Based on elastic short-range interactions we map this physical process onto an Ising-like model, which enables us to predict the clustering of channels and the effects of clustering on their gating. We conclude that the aggregation of channels and the consequent interactions among them leads to a global cooperative gating behaviour with potentially dramatic consequences for the cell.