标题： 收缩丝束的粘弹性响应 显示英文标题

标题： Viscoelastic response of contractile filament bundles

摘要： 粘附组织细胞的肌动蛋白细胞骨架通常会浓缩成由肌球蛋白马达收缩的纤维束，即所谓的应力纤维，它们在细胞与环境的机械相互作用中起着关键作用。 应力纤维通常在其端点与环境相连，但可能也沿着整个长度连接。 我们引入了一个用于这种收缩纤维束的理论模型，该模型结合了被动的粘弹性与主动的收缩性。 该模型方程针对两种不同类型的边界条件进行了解析求解。 自由边界对应于激光手术后应力纤维的收缩动力学，并与实验数据有良好的一致性。 施加周期性变化的边界力使我们能够计算单个应力纤维的复数模量。 显示英文摘要

摘要： The actin cytoskeleton of adherent tissue cells often condenses into filament bundles contracted by myosin motors, so-called stress fibers, which play a crucial role in the mechanical interaction of cells with their environment. Stress fibers are usually attached to their environment at the endpoints, but possibly also along their whole length. We introduce a theoretical model for such contractile filament bundles which combines passive viscoelasticity with active contractility. The model equations are solved analytically for two different types of boundary conditions. A free boundary corresponds to stress fiber contraction dynamics after laser surgery and results in good agreement with experimental data. Imposing cyclic varying boundary forces allows us to calculate the complex modulus of a single stress fiber.