标题： 物理方法在基因电路动力学中的应用：教程 显示英文标题

标题： Physical approaches to the dynamics of genetic circuits: A tutorial

摘要： 细胞行为由内在动态且非线性的基因调控过程所支配，并受到不可忽略的随机波动的影响。 这些条件在物理系统中很普遍，多年来已通过统计物理和非线性物理的工具进行研究。 本综述的目标是展示传统上用于物理学的方法如何有助于对活细胞进行系统层面的理解。 为此，我们概述了基因电路所表现出的动力学现象及其功能意义。 我们还描述了理论和实验方法，这些方法正在被用来解析在噪声影响下，电路结构与功能之间的关系，既在单细胞水平上，也在细胞群体中，其中细胞间耦合起着重要作用。 显示英文摘要

摘要： Cellular behavior is governed by gene regulatory processes that are intrinsically dynamic and nonlinear, and are subject to non-negligible amounts of random fluctuations. Such conditions are ubiquitous in physical systems, where they have been studied for decades using the tools of statistical and nonlinear physics. The goal of this review is to show how approaches traditionally used in physics can help in reaching a systems-level understanding of living cells. To that end, we present an overview of the dynamical phenomena exhibited by genetic circuits and their functional significance. We also describe the theoretical and experimental approaches that are being used to unravel the relationship between circuit structure and function in dynamical cellular processes under the influence of noise, both at the single-cell level and in cellular populations, where intercellular coupling plays an important role.