标题： 基因表达的调控通过调节自组装 显示英文标题

标题： Control of gene expression by modulated self-assembly

摘要： 许多转录因子以细胞主动调控的方式自我组装成不同有序的寡聚体物种。 到目前为止，尚未确定这一广泛过程的一般功能作用。 在这里，我们通过一种新的定量框架捕捉调节自组装对基因表达的影响。 我们表明，这种机制为感知多种细胞信号的系统提供了精确性和灵活性，这两种看似对立的特性，这些系统包含转录因子如p53、NF-kappaB、STATs、Oct和RXR中的共同元件。 应用于核激素受体RXR，这个框架准确地再现了一组广泛的经典、此前无法解释的基因表达数据，并证实了一个具有灵活特性的精确功能区间的存在，该区间可以在全基因组水平和单个启动子水平上进行控制。 显示英文摘要

摘要： Numerous transcription factors self-assemble into different order oligomeric species in a way that is actively regulated by the cell. Until now, no general functional role has been identified for this widespread process. Here we capture the effects of modulated self-assembly in gene expression with a novel quantitative framework. We show that this mechanism provides precision and flexibility, two seemingly antagonistic properties, to the sensing of diverse cellular signals by systems that share common elements present in transcription factors like p53, NF-kappaB, STATs, Oct, and RXR. Applied to the nuclear hormone receptor RXR, this framework accurately reproduces a broad range of classical, previously unexplained, sets of gene expression data and corroborates the existence of a precise functional regime with flexible properties that can be controlled both at a genome-wide scale and at the individual promoter level.