标题： 宿主内免疫反应对内脏线虫病和疟疾共感染的建模及预防措施 显示英文标题

标题： Modelling Within-Host Immune Response to Visceral Helminthiasis and Malaria Co-infection with Prophylaxis

摘要： 在本文中，研究了疟疾和内脏线虫病共同感染以及免疫刺激和损害的情况。 我们假设个体在线虫幼虫入侵期间感染疟疾。 在没有免疫反应的情况下，我们的结果表明，如果每个入侵的裂殖子破坏红细胞的速率大于一，则抗原会侵入血液系统。 如果释放的裂殖子较少，初始状态是全局渐近稳定的。 如果释放更多的裂殖子，就会存在仅疟疾的流行点。 然而，如果平均感染负担大于一，两种抗原都会共存。 在这种情况下，存在一个药物作用的阈值，低于该阈值时预期宿主无法恢复。 在存在免疫反应的情况下，存在三个平衡状态。 初始入侵状态，其次是在免疫种群被激活且抗原被消除时的不稳定状态。 第三种状态代表流行状态，如果在免疫激活下每红细胞的感染诱导破裂率小于红细胞的总死亡率，则该状态是稳定的。 一个关于共同感染严重程度的模型表明，免疫反应将被延迟，直到疟疾和线虫的免疫屏障值被超过。 显示英文摘要

摘要： In this paper, a co-infection of malaria and visceral helminthiasis with immune stimulation and impairment is studied. We have assumed that an individual gets malaria infection during invasion by helminths larvae. In absence of immune response, our results show that the antigens invade the blood system if the rate of red cell rupture per invading merozoite is greater than one. If fewer merozoites are released, the initial state is globally asymptotically stable. If more merozoites are released, there exists malaria-only endemic point. However, both antigens coexist if the mean infection burden is greater than one. In this case, there is a threshold value for drug action below which no recovery of host is expected. In presence of immune response, three equilibrium states exist. The initial invasion state, and secondly, the unstable state when the immune population has been triggered and the antigens have been eliminated. The third state represents the endemic state which is stable if the infection-induced rupture rate per erythrocyte with immune activation is less than the total mortality of the erythrocytes. A model for severity of the co-infection shows that an immune response will be delayed until immunological barrier values for malaria and helminths are exceeded.