标题： 从受孕到绝经的血清抗穆勒氏激素的有效模型 显示英文标题

标题： A validated model of serum anti-Mullerian hormone from conception to menopause

摘要： 背景：抗穆勒氏激素（AMH）是生长中的卵巢卵泡的产物。 血液中AMH的浓度也可能反映非生长卵泡（NGF）群体，即卵巢储备，并可能在预测生殖寿命方面具有价值。 尚未有对更年期前AMH产生的完整描述。 方法学/主要发现：通过搜索健康绝经前女性的AMH浓度的已发表文献，并使用我们自己的数据（总样本量=3,260），我们生成并严格验证了从受孕到更年期的AMH浓度的第一个模型。 该模型显示，AMH变化的34%仅由年龄单独导致。 我们证明AMH在24.5岁时达到峰值，随后下降至更年期。 我们还证明存在新生儿期的峰值和潜在的青春期前峰值。 我们的模型使我们能够在所有年龄生成正常值。 结论/意义：这些数据突出了卵巢卵泡动力学中的关键转折点。 这个首次经过验证的健康女性循环AMH模型描述了一个早期成年期的过渡期，在此之后，AMH反映了NGF池的逐渐丧失。 女性生殖腺活动的新生儿期增加得到了确认。 对循环AMH与年龄之间关系的更好理解将导致对个体女性卵巢储备更准确的评估。 显示英文摘要

摘要： Background: Anti-Mullerian hormone (AMH) is a product of growing ovarian follicles. The concentration of AMH in blood may also reflect the non-growing follicle (NGF) population, i.e. the ovarian reserve, and be of value in predicting reproductive lifespan. A full description of AMH production up to the menopause has not been reported. Methodology/Principal Findings: By searching the published literature for AMH concentrations in healthy pre-menopausal females, and using our own data (combined n = 3,260) we have generated and robustly validated the first model of AMH concentration from conception to menopause. This model shows that 34% of the variation in AMH is due to age alone. We have shown that AMH peaks at age 24.5 years, followed by a decline to the menopause. We have also shown that there is a neonatal peak and a potential pre-pubertal peak. Our model allows us to generate normative data at all ages. Conclusions/Significance: These data highlight key inflection points in ovarian follicle dynamics. This first validated model of circulating AMH in healthy females describes a transition period in early adulthood, after which AMH reflects the progressive loss of the NGF pool. The existence of a neonatal increase in gonadal activity is confirmed for females. An improved understanding of the relationship between circulating AMH and age will lead more accurate assessment of ovarian reserve for the individual woman.