标题： 从受孕到绝经的人类卵巢储备 显示英文标题

标题： Human ovarian reserve from conception to the menopause

摘要： 人类卵巢包含在出生前建立的固定数量的非生长卵泡（NGFs），这些卵泡随着年龄增长而减少，最终在50-51岁时达到绝经期。 本研究的目的是从受孕到绝经期建模人类卵巢中与年龄相关的NGF种群。 数据来自八项独立的定量组织学研究（n = 325），其中计算了从受孕后七周到51岁（中位数32岁）已知年龄的NGF种群。 数据集被拟合到20个峰值函数模型，结果根据获得的r2相关系数进行排序。 选择了排名最高的模型。 我们的模型将从受孕到绝经期的对数调整后的NGF种群与五参数不对称双高斯累积（ADC）曲线相匹配（r2 = 0.81）。 当限制在25岁以内的年龄时，ADC曲线的r2为0.95。 我们估计，对于95%的女性来说，到30岁时，其最大出生前NGF种群的只有12%存在，到40岁时只剩下3%。 此外，我们发现大多数女性的NGF募集向成熟的速度从出生到大约14岁增加，然后逐渐减少直到绝经期。 据我们所知，这是从受孕到绝经期的第一个卵巢储备模型。 该模型使我们能够估计在任何给定年龄卵巢中存在的NGF数量，表明81%的NGF种群方差仅由年龄引起，并首次显示（据我们所知），NGF募集速率从出生到14岁增加，然后随着年龄增长直到绝经期而下降。 对人类卵巢储备动态的更深入理解将为健康女性以及那些经历了性腺毒性癌症治疗的女性的生育咨询提供更科学的基础。 显示英文摘要

摘要： The human ovary contains a fixed number of non-growing follicles (NGFs) established before birth that decline with increasing age culminating in the menopause at 50-51 years. The objective of this study is to model the age-related population of NGFs in the human ovary from conception to menopause. Data were taken from eight separate quantitative histological studies (n = 325) in which NGF populations at known ages from seven weeks post conception to 51 years (median 32 years) were calculated. The data set was fitted to 20 peak function models, with the results ranked by obtained r2 correlation coefficient. The highest ranked model was chosen. Our model matches the log-adjusted NGF population from conception to menopause to a five-parameter asymmetric double Gaussian cumulative (ADC) curve (r2 = 0.81). When restricted to ages up to 25 years, the ADC curve has r2 = 0.95. We estimate that for 95% of women by the age of 30 years only 12% of their maximum pre-birth NGF population is present and by the age of 40 years only 3% remains. Furthermore, we found that the rate of NGF recruitment towards maturation for most women increases from birth until approximately age 14 years then decreases towards the menopause. To our knowledge, this is the first model of ovarian reserve from conception to menopause. This model allows us to estimate the number of NGFs present in the ovary at any given age, suggests that 81% of the variance in NGF populations is due to age alone, and shows for the first time, to our knowledge, that the rate of NGF recruitment increases from birth to age 14 years then declines with age until menopause. An increased understanding of the dynamics of human ovarian reserve will provide a more scientfic basis for fertility counselling for both healthy women and those who have survived gonadotoxic cancer treatments.