标题： 药物作用的热力学：在林氏生命细胞模型背景下，电子受体化合物对活化或受损细胞的作用 显示英文标题

标题： Thermodynamics of pharmacological action for electron-accepting compounds on activated or damaged cell in the context of Ling's model of the living cell

摘要： 描述本文中药物作用的理论基于这样一个假设：细胞的活力可以用两种状态的模型来描述：静止状态和兴奋状态。 根据现有的生理数据，兴奋状态对细胞是有害的，可能导致不同的病理变化，包括由于蛋白质聚集引起的“构型”疾病。 通常，兴奋状态是完全可逆的，这里的关键作用是由ATP（腺苷-5'-三磷酸）发挥的，它使细胞基质的蛋白质解聚。 ATP在细胞损伤期间也产生相同的效应，引发“修复”效果。 我们认为细胞结构的损伤是“疾病”，而去除由任何原因引起的蛋白质聚集造成的病理后果我们将称之为“治愈”。 后者被视为细胞从兴奋/损伤恢复到静止状态的物理过程，这是在我们广义热力学的框架下进行分析的。 “治愈”导致细胞蛋白质的有效温度降低，这是由于结合了细胞内浓度约为44 M的水分。 由于吸附过程，水和蛋白质的流动性大大降低，相应的有效温度降低被我们视为治疗效果的衡量标准。 显示英文摘要

摘要： The theory describing action of medicines explored in this paper is based on assumption that vital activity of the cell may be described in terms of the model of two states: resting state and excitation. According to available physiological data excitation state is dangerous for cell and may cause different pathological changes, including "conformational" diseases, due to protein aggregation. Normally, the excitation is completely reversible and the key role is played here by ATP (adenosine-5'-triphosphate) which disaggregates proteins of cytomatrix. The same effect ATP exerts during cell injury by eliciting a "healing" effect. Damage of cell structures we consider as "illness", whereas removal of pathological consequences caused by protein aggregation of any origin we will call "a cure". The latter is considered as physical process of cell recovering from excitation/injury to resting state, which is analyzed in terms of our generalized thermodynamics. "Cure" results in reduction of effective temperature of cell proteins due to binding intracellular water which is present in the cell at concentration of approximately 44 M. As a result of the sorption processes mobility of both water and proteins is greatly reduced, and the corresponding reduction of the effective temperature seen by us as a measure of treatment effect.