标题： 货物运输的分子马达团队随机建模 显示英文标题

标题： Stochastic modeling of cargo transport by teams of molecular motors

摘要： 许多不同类型的细胞货物通过分子马达团队在微管上进行双向运输。 该货物-马达系统的运动在体内被实验表征为具有相当持久方向性的过程性运动。 为了探索这种运动的起源，已经提出了不同的理论方法。 Müller等人提出的一种有效理论方法将货物动力学描述为不同种类马达之间的拔河现象。 Kunwar等人最近提出了一种替代方法，他们更详细地考虑了马达与货物之间的耦合。 基于这一框架，我们引入了一个模型，该模型考虑单个马达的位置，并在连续时间内进行传播。 此外，我们分析了先前出版物中使用的离散时间更新方案对系统动力学的可能影响。 显示英文摘要

摘要： Many different types of cellular cargos are transported bidirectionally along microtubules by teams of molecular motors. The motion of this cargo-motors system has been experimentally characterized in vivo as processive with rather persistent directionality. Different theoretical approaches have been suggested in order to explore the origin of this kind of motion. An effective theoretical approach, introduced by M\"uller et al., describes the cargo dynamics as a tug-of-war between different kinds of motors. An alternative approach has been suggested recently by Kunwar et al., who considered the coupling between motor and cargo in more detail. Based on this framework we introduce a model considering single motor positions which we propagate in continuous time. Furthermore, we analyze the possible influence of the discrete time update schemes used in previous publications on the system's dynamic.