标题： 一种由DNA制成并由DNA驱动的合成自主旋转纳米马达 显示英文标题

标题： A synthetic autonomous rotary nanomotor made from and fuelled by DNA

摘要： DNA纳米结构是通过合成的DNA链制造的，这些链的序列被设计成能够通过互补区域的杂交自组装成所需的形状。 已经提出了各种结构和装置，包括DNA镊子、纳米机器人以及一系列线性马达，如双足行走器。 后者的设计灵感来源于天然存在的分子马达，如驱动蛋白。 本文描述了一种由DNA制成的自主旋转纳米马达的概念，该马达利用了众所周知且广泛研究的踏脚-mediated DNA链置换现象。 该马达将通过一系列链置换反应驱动，这些反应的顺序由构成马达机制的DNA链的二级结构产生的立体约束控制。 如果能够实现自主旋转运动，DNA马达的能力将得到显著扩展。 该装置具有多种潜在应用，包括分子计算和单分子操控。 显示英文摘要

摘要： DNA nanostructures are made using synthetic DNA strands, the sequences of which are designed such that they will self-assemble into the desired form by hybridization of complementary domains. Various structures and devices have been presented, including DNA tweezers, nanorobots and a range of linear motors such as bipedal walkers. Inspiration for the latter is drawn from naturally occurring molecular motors like kinesin. This paper describes a concept for an autonomous rotary nanomotor made from DNA, which utilizes the well-known and widely-studied phenomenon of toehold-mediated DNA strand displacement. The motor is to be driven by a series of strand displacement reactions, the order of which is controlled by steric constraints arising from the secondary structure of the DNA strands comprising the motor mechanism. The capabilities of DNA motors would be extended significantly if autonomous rotary motion could be achieved. The device has a range of potential applications, including molecular computation and single-molecule manipulation.