标题： 多细胞系统的定量设计原理的研究进展 显示英文标题

标题： Progress towards quantitative design principles of multicellular systems

摘要： 生命系统，特别是多细胞系统，通常看起来复杂得令人绝望。 但最近的研究表明，在这种复杂性之下，可能有统一的定量原则，而我们才刚刚开始解开这些原则。 所有细胞都与其环境和其他细胞相互作用。 细胞之间的通信是细胞相互作用的主要方式。 由于细胞数量庞大以及细胞内和细胞间相互作用的多样性，这些多细胞系统的复杂性使得理解多细胞系统成为一个艰巨的任务。 为了克服这一挑战，我们可能需要谨慎的简化和概念框架，这些框架能够揭示在各种多细胞系统中共享的设计原则。 在这里，我们回顾了一些最近在开发此类框架方面的进展。 显示英文摘要

摘要： Living systems, particularly multicellular systems, often seem hopelessly complex. But recent studies have suggested that beneath this complexity, there may be unifying quantitative principles that we are only now starting to unravel. All cells interact with their environments and with other cells. Communication among cells is a primary means for cells to interact with each other. The complexity of these multicellular systems, due to the large numbers of cells and the diversity of intracellular and intercellular interactions, makes understanding multicellular systems a daunting task. To overcome this challenge, we will likely need judicious simplifications and conceptual frameworks that can reveal design principles that are shared among diverse multicellular systems. Here we review some recent progress towards developing such frameworks.