标题： 谷氨酸能胶质递质对突触可塑性的调节：建模研究 显示英文标题

标题： Modulation of synaptic plasticity by glutamatergic gliotransmission: A modeling study

摘要： 谷氨酸能胶质传递，即在活动依赖性下从突触周围星形胶质细胞过程释放谷氨酸，已被认为是调节突触可塑性的潜在关键信号通路，但其在体内的表达模式和功能仍不清楚。 在这里，我们关注两种实验上明确的胶质传递途径： (i) 突触释放的调节以及 (ii) 由星形胶质细胞释放的谷氨酸介导的突触后缓慢内向电流，并研究它们在星形胶质细胞调控的突触的生物物理模型中对突触可塑性的可能功能相关性。 我们的模型预测，这两种途径都可能深刻影响短期和长期的可塑性。 特别是，星形胶质细胞的活动依赖性谷氨酸释放，可能会显著改变尖峰时间依赖性可塑性，使同一协议的增强变为抑制（反之亦然）。 显示英文摘要

摘要： Glutamatergic gliotransmission, that is the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic plasticity, yet its modes of expression and function in vivo remain unclear. Here, we focus on two experimentally well-identified gliotransmitter patwhays: (i)~modulations of synaptic release and (ii)~postynaptic slow inward currents mediated by glutamate released from astrocytes, and investigate their possible functional relevance on synaptic plasticity in a biophysical model of an astrocyte-regulated synapse. Our model predicts that both pathways could profoundly affect both short- and long-term plasticity. In particular, activity-dependent glutamate release from astrocytes, could dramatically change spike-timing--dependent plasticity, turning potentiation into depression (and vice versa) for the same protocol.