标题： 淀粉样蛋白 fibrillation 的统计力学和动力学 显示英文标题

标题： Statistical Mechanics and Kinetics of Amyloid Fibrillation

摘要： 淀粉样蛋白纤维化是一种与众所周知的人类神经退行性疾病密切相关的蛋白质自组装现象。在过去几十年里，我们在理解这一现象物理起源方面取得了显著进展，这些构成了本综述的内容。 从淀粉样蛋白纤维的最小模型出发，我们系统地探索了稀释和半稀释极限下淀粉样蛋白纤维化的平衡和动力学方面。 然后，我们将进一步的分子机制纳入分析中。 我们还讨论了基于化学质量作用方程的动力学建模的数学基础、与实验测量的定量联系以及执行全局拟合的步骤。 显示英文摘要

摘要： Amyloid fibrillation is a protein self-assembly phenomenon that is intimately related to well-known human neurodegenerative diseases. During the past few decades, striking advances have been achieved in our understanding of the physical origin of this phenomenon and they constitute the contents of this review. Starting from a minimal model of amyloid fibrils, we explore systematically the equilibrium and kinetic aspects of amyloid fibrillation in both dilute and semi-dilute limits. We then incorporate further molecular mechanisms into the analyses. We also discuss the mathematical foundation of kinetic modeling based on chemical mass-action equations, the quantitative linkage with experimental measurements, as well as the procedure to perform global fitting.