标题： 一对离子通道的周期性尖峰 显示英文标题

标题： Periodic spiking by a pair of ionic channels

摘要： 神经元细胞表现出涉及大量不同离子通道的局部电压尖峰周期性序列。 一个相关的问题是，这是否是一种协同效应，或者也可能是单个通道的固有特性。 在这里，我们使用朗之万公式来描述一对钠和钾离子通道的随机动力学。 这两个通道是简单的门控孔模型，其中最少数量的自由度遵循标准统计物理。 整个系统是完全自主的，除了膜两侧不同离子浓度的化学能外，没有任何外部能量输入。 结果表明，一对不同的离子通道可以维持膜电位的周期性尖峰。 尖峰是由于膜电位、离子流以及每个通道结构内部部分（门）的动力学之间的相互作用引起的。 尖峰涉及一系列动态步骤，其中最重要的是钠离子的泄漏。 缺失的尖峰事件是由特定模型部分功能异常引起的。 时间依赖的尖峰结构与实验数据相比较接近。 显示英文摘要

摘要： Neuronal cells present periodic trains of localized voltage spikes involving a large amount of different ionic channels. A relevant question is whether this is a cooperative effect or it could also be an intrinsic property of individual channels. Here we use a Langevin formulation for the stochastic dynamics of a pair of Na and K ionic channels. These two channels are simple gated pore models where a minimum set of degrees of freedom follow standard statistical physics. The whole system is totally autonomous without any external energy input, except for the chemical energy of the different ionic concentrations across the membrane. As a result it is shown that a unique pair of different ionic channels can sustain membrane potential periodic spikes. The spikes are due to the interaction between the membrane potential, the ionic flows and the dynamics of the internal parts (gates) of each channel structures. The spike involves a series of dynamical steps being the more relevant one the leak of Na ions. Missing spike events are caused by the altered functioning of specific model parts. The time dependent spike structure is comparable with experimental data.