标题： 组织竞争的力学：界面稳定共存 显示英文标题

标题： Mechanics of tissue competition: Interfaces stabilize coexistence

摘要： 机械力影响生长组织的动力学。 计算机模拟被用于研究界面效应在组织竞争中的重要性。 推测机械压力决定了竞争，其中决定性量是稳态压力——分裂和凋亡平衡时的压力；稳态压力较高的组织会压倒其他组织。 令人惊讶的是，如果两者之间的粘附足够小，较弱的组织可以与较强的组织稳定共存。 一种解析连续描述可以定量描述其潜在机制并再现产生的压力和细胞数比例。 计算机模拟还显示了各种共存结构，从球形包含物到双连续状态。 显示英文摘要

摘要： Mechanical forces influence the dynamics of growing tissues. Computer simulations are employed to study the importance of interfacial effects in tissue competition. It was speculated that mechanical pressure determines the competition, where the determining quantity is the homeostatic pressure - the pressure where division and apoptosis balance; the tissue with the higher homeostatic pressure overwhelms the other. Surprisingly, a weaker tissue can persist in stable coexistence with a stronger tissue, if adhesion between them is small enough. An analytic continuum description can quantitatively describe the underlying mechanism and reproduce the resulting pressures and cell-number fractions. Computer simulations furthermore display a variety of coexisting structures, ranging from spherical inclusions to a bicontinuous state.