标题： 一种全球核酸观测站用于生物防御和行星健康 显示英文标题

标题： A Global Nucleic Acid Observatory for Biodefense and Planetary Health

摘要： 流行病毒和入侵物种的传播对人类社会和自然生态系统可能造成灾难性影响。 SARS-CoV-2表明，我们的应对速度至关重要，因为每天的延迟都会导致病毒的指数级增长和扩散。 在此，我们提出一个全球核酸观测站（NAO），通过全面的宏基因组测序监测水道和污水中的所有生物相对频率。 通过在全球各地的站点搜索与历史基线频率的差异，NAO可以检测到任何正在经历指数增长并最终进入水中的病毒或入侵生物，即使这些生物目前尚未被科学所知。 持续监测核酸多样性将为我们提供普遍的早期预警，消除微妙的生物武器，并生成大量足以改变生态学、微生物学和保护工作的序列数据。 我们呼吁立即建设全球NAO，以保护和揭示地球健康。 显示英文摘要

摘要： The spread of pandemic viruses and invasive species can be catastrophic for human societies and natural ecosystems. SARS-CoV-2 demonstrated that the speed of our response is critical, as each day of delay permitted exponential growth and dispersion of the virus. Here we propose a global Nucleic Acid Observatory (NAO) to monitor the relative frequency of everything biological through comprehensive metagenomic sequencing of waterways and wastewater. By searching for divergences from historical baseline frequencies at sites throughout the world, NAO could detect any virus or invasive organism undergoing exponential growth whose nucleic acids end up in the water, even those previously unknown to science. Continuously monitoring nucleic acid diversity would provide us with universal early warning, obviate subtle bioweapons, and generate a wealth of sequence data sufficient to transform ecology, microbiology, and conservation. We call for the immediate construction of a global NAO to defend and illuminate planetary health.