标题： 从实验设计的角度看群体遗传变异 显示英文标题

标题： An Experimental-Design Perspective on Population Genetic Variation

摘要： 我们考虑一个假设，即进化促进了种群范围内的基因组模式，在随机化下确保了适应在种群成员之间的外部有效性。 如果一种适应在其效果在广泛的种群遗传变异下都成立，则该适应是外部有效的（EV）。 根据该假设的一个预测是，分离区域中的成对碱基替换必须是“随机”的，如同Erdos-Renyi-Gilbert随机图一样，但边的概率是从实验设计概念中得出的。 我们在2504个成年人、1135种开花植物、1170只果蝇、453只家羊和1223只棕鼠的全基因组中展示了这些概率以及相应的突变率。 显示英文摘要

摘要： We consider the hypothesis that Evolution promotes population-wide genome patterns that, under randomization, ensures the External Validity of adaptations across population members. An adaptation is Externally Valid (EV) if its effect holds under a wide range of population genetic variations. A prediction following the hypothesis is that pairwise base substitutions in segregating regions must be 'random' as in Erdos-Renyi-Gilbert random graphs, but with edge probabilities derived from Experimental-Design concepts. We demonstrate these probabilities, and consequent mutation rates, in the full-genomes of 2504 humans, 1135 flowering plants, 1170 flies, 453 domestic sheep and 1223 brown rats.