标题： 局部接触抑制导致细胞群体生长的普遍规律 显示英文标题

标题： Local contact inhibition leads to universal principles of cell population growth

摘要： 癌细胞种群动力学往往表现出显著可重复的普遍规律，尽管其底层具有异质性。 至今，普遍细胞种群增长的机制解释仍部分未解，其中微观和介观构型之间的种群反馈可能导致宏观增长规律。 我们在此通过接触抑制提出了密度依赖性出生事件下的统一理论。 我们考虑了五种经典的肿瘤生长定律：指数增长、广义逻辑斯蒂增长、Gompertz增长、径向增长和分形增长，这些可以被视为单一微观模型的表现形式。 我们的理论得到了基于代理的模拟验证，并可以解释体外癌细胞种群增长实验数据中的生长曲线差异。 因此，我们的框架为大量能够充分捕捉看似无关的癌症或微生物增长动力学的平均场定律提供了一个可能的解释。 显示英文摘要

摘要： Cancer cell population dynamics often exhibit remarkably replicable, universal laws despite their underlying heterogeneity. Mechanistic explanations of universal cell population growth remain partly unresolved to this day, whereby population feedback between the microscopic and mesoscopic configurations can lead to macroscopic growth laws. We here present a unification under density-dependent birth events via contact inhibition. We consider five classical tumor growth laws: exponential, generalized logistic, Gompertz, radial growth, and fractal growth, which can be seen as manifestations of a single microscopic model. Our theory is substantiated by agent based simulations and can explain growth curve differences in experimental data from in vitro cancer cell population growth. Thus, our framework offers a possible explanation for the large number of mean-field laws that can adequately capture seemingly unrelated cancer or microbial growth dynamics.