标题： 一种最小生物体经验依赖行为的多尺度感觉运动模型 显示英文标题

标题： A multiscale sensorimotor model of experience-dependent behavior in a minimal organism

摘要： 为了在不断变化的环境中生存，生物体需要不断结合它们接收到的持续外部输入，以代表当前状况，并与包含过去经验影响的动力学内部状态相结合。 然而，目前尚不清楚的是，（i）这在分子和细胞水平上是如何发生的，以及（ii）相应的分子和细胞过程如何与生物体的行为反应整合在一起。 在此，我们通过在一种最小模型生物体中建立数学模型来解决这些问题，即线虫 C. elegans 的趋化行为。 具体而言，我们使用了关于这种动物盐趋化性的长期实验数据，其中迁移方向取决于其之前的经历。 我们的模型整合了分子、细胞和生物体层面，以再现实验观察到的经验依赖行为。 该模型提出了关键神经元中当前状况和过去经验编码的具体分子机制，并预测了与这些分子回路相关的各种突变体的行为。 显示英文摘要

摘要： To survive in ever-changing environments, living organisms need to continuously combine the ongoing external inputs they receive, representing present conditions, with their dynamical internal state, which includes influences of past experiences. It is still unclear in general, however, (i) how this happens at the molecular and cellular levels, and (ii) how the corresponding molecular and cellular processes are integrated with the behavioral responses of the organism. Here we address these issues by modeling mathematically a particular behavioral paradigm in a minimal model organism, namely chemotaxis in the nematode C. elegans. Specifically, we use a long-standing collection of elegant experiments on salt chemotaxis in this animal, in which the migration direction varies depending on its previous experience. Our model integrates the molecular, cellular and organismal levels to reproduce the experimentally observed experience-dependent behavior. The model proposes specific molecular mechanisms for the encoding of current conditions and past experiences in key neurons associated with this response, predicting the behavior of various mutants associated with those molecular circuits.