标题： 红细胞聚集运输有限浓度 显示英文标题

标题： Red blood cells aggregates transport for finite concentration

摘要： 红细胞（RBCs）负责将氧气和各种代谢物运输到组织和器官，同时清除废物。 多种心血管疾病可能损害这些功能。 例如，在糖尿病中，增加的RBC聚集可能导致血液阻塞，从而导致组织无法有效输送氧气。 有趣的是，RBC粘附不仅发生在疾病状态下，也在生理条件下发生，关键区别在于在健康情况下粘附是可逆的。 本文专注于二维数值模拟，探讨不同的粘附能（包括生理和病理情况）以及变化的流速和血细胞比容水平。 进行了RBC通量和粘度的系统分析。 一个显著的发现是，适度的粘附能（在生理范围内）增强了RBC的运输，从而改善了组织的氧气输送。 这为为什么在正常情况下存在RBC粘附提供了见解。 相反，当粘附能超过一定阈值时，会导致RBC通量崩溃，从而减少氧气运输。 我们对粘附能对血流效率的非单调效应提供了基本解释。 这一发现是在处理由现实微血管启发的复杂网络中的这一问题之前，理解RBC粘附影响（正负两方面）的初步步骤。 显示英文摘要

摘要： Red blood cells (RBCs) are responsible for transporting oxygen and various metabolites to tissues and organs, as well as removing waste. Several cardiovascular diseases can impair these functions. For instance, in diabetes, increased RBC aggregation can lead to blood occlusion, thereby depriving tissues of efficient oxygen delivery. Interestingly, RBC adhesion occurs not only in disease states but also under physiological conditions, with the key difference being that adhesion is reversible in healthy situations. This paper focuses on numerical simulations in 2D, exploring different adhesion energies (both physiological and pathological) alongside varying flow strengths and hematocrit levels. A systematic analysis of RBC flux and viscosity is conducted. A remarkable finding is that moderate adhesion energy (within the physiological range) enhances RBC transport, thereby improving oxygen delivery to tissues. This provides insight into why RBC adhesion is present under normal conditions. Conversely, increasing adhesion energy beyond a certain point causes a collapse in RBC flux, thus reducing oxygen transport. We provide a basic explanation for the non-monotonic effect of adhesion energy on blood flow efficiency. This finding serves as an initial step in understanding the impact (both positive and negative) of RBC adhesion before addressing this issue in complex networks inspired by realistic microvasculatures.