标题： 基于硬件和软件的运动校正的人体皮肤在体动态光学相干断层扫描 显示英文标题

标题： In vivo dynamic optical coherence tomography of human skin with hardware- and software-based motion correction

摘要： 在活体中应用动态光学相干断层扫描（DOCT）受到样本整体运动的阻碍。 我们通过采用样本固定附件来抑制整体运动，并随后使用软件运动校正进一步减少样本运动的影响，实现了对\invivo 人类皮肤的DOCT成像。 通过DOCT图像观察、平均DOCT值的统计分析以及主观图像评分来评估运动校正方法的性能。 平均DOCT值分析和主观评分均显示DOCT图像质量有统计学上的显著改善。 此外，通过图像观察发现了一个之前未观察到的高DOCT层，这可能代表了具有高角质形成细胞增殖的基底层。 显示英文摘要

摘要： In vivo application of dynamic optical coherence tomography (DOCT) is hindered by bulk motion of the sample. We demonstrate DOCT imaging of \invivo human skin by adopting a sample-fixation attachment to suppress bulk motion and a subsequent software motion correction to further reduce the effect of sample motion. The performance of the motion-correction method was assessed by DOCT image observation, statistical analysis of the mean DOCT values, and subjective image grading. Both the mean DOCT value analysis and subjective grading showed statistically significant improvement of the DOCT image quality. In addition, a previously unobserved high DOCT layer was identified though image observation, which may represent the stratum basale with high keratinocyte proliferation.