标题： CRYSP：基于低温碘化铯晶体的全身PET 显示英文标题

标题： CRYSP: a Total-Body PET based on cryogenic cesium iodide crystals

摘要： 全身正电子发射断层扫描（TBPET）扫描仪最近展示了显著减少采集时间和给予的放射性剂量的能力，这是由于它们的灵敏度提高。 然而，由于当前可用系统的高昂成本，它们的广泛应用受到限制。 在这一背景下，纯碘化铯（CsI）单块晶体因其与目前使用的稀土晶体相比成本低得多，为提高可及性提供了一个有前景的解决方案。 当在低温温度下运行（约100 K）时，CsI晶体在无机晶体中表现出最高的光输出之一，约为$10^5$光子/MeV。 这导致能量分辨率低于7%，毫米级空间分辨率（包括准确的相互作用深度确定），以及纳秒级符合时间分辨率，尽管它们的闪烁衰减时间相对较慢。 本研究证明，基于低温CsI单块晶体的TBPET扫描仪可能比传统系统具有在降低成本的同时提供高性能成像的潜力，为更广泛的部署和可及性铺平了道路。 显示英文摘要

摘要： Total Body PET (TBPET) scanners have recently demonstrated the ability to significantly reduce both acquisition time and the administered radioactive dose, thanks to their increased sensitivity. However, their widespread adoption is limited by the high costs associated with the current available systems. In this context, pure cesium iodide (CsI) monolithic crystals, given their much lower cost compared with currently used rare-earth crystals, offer a promising solution to improve accessibility. When operated at cryogenic temperatures (approximately 100 K), CsI crystals exhibit one of the highest light outputs among inorganic crystals, around $10^5$ photons/MeV. This results in energy resolution below 7%, millimeter-scale spatial resolution (including accurate depth-of-interaction determination), and coincidence time resolution at the nanosecond level, despite their relatively slow scintillation decay time. This study demonstrates that a TBPET scanner based on cryogenic CsI monolithic crystals might have the potential to deliver high-performance imaging at a reduced cost compared with conventional systems, paving the way for broader deployment and accessibility.