标题： 等离子体增强的超光谱成像 显示英文标题

标题： Plasmon-enhanced Hyperspectral Imaging

摘要： 高光谱成像由于其能够增强组织对比度，超越传统明场成像技术的能力，在疾病诊断领域正受到越来越多的关注。 通常，组织切片在可见光谱范围内缺乏足够的固有对比度，需要使用染料或染色剂进行适当的可视化。 然而，最近的一项突破是将等离子体超材料作为组织切片的基底，取代传统显微镜载玻片上的染色或标记。 这些纳米制造的显微镜载玻片，简称为 nanoMslides，通过在白光照射下根据样品中的折射率变化选择性地传输颜色来工作。 本研究探讨了将 nanoMslides 用于高光谱成像的可行性。 通过使用可调光源，可以有选择地激发载玻片中的特定等离子体共振。 对等离子体相互作用的精确控制导致灵敏度和特异性显著提高，展示了在疾病诊断和生物医学研究中先进应用的潜力。 显示英文摘要

摘要： Hyperspectral imaging is gaining attention in the field of disease diagnosis due to its ability to enhance tissue contrast, surpassing the capabilities of conventional brightfield imaging techniques. Typically, histological sections lack sufficient intrinsic contrast in the visible spectrum, necessitating the use of dyes or stains for adequate visualization. However, a recent breakthrough involves the application of plasmonic meta-materials as substrates for histological sections, replacing staining or labelling on traditional microscope glass slides. These nanofabricated microscope slides, shortened to nanoMslides, operate by selectively transmitting colors based on refractive index variations within the sample when illuminated with white light. This study investigates the feasibility of integration of nanoMslides for hyperspectral imaging. By employing a tunable light source, specific plasmon resonances within the slides can be selectively excited. This precise control over plasmonic interactions results in significantly heightened sensitivity and specificity, showcasing the potential for advanced applications in disease diagnosis and biomedical research.