标题： 超声波触发的抗癌纳米颗粒从集成软体机械触手的电纺织物中的释放 显示英文标题

标题： Ultrasound-Triggered Release of Anticancer Nanoparticles from Electrospun Fabrics Integrated with Soft Robotic Tentacles

摘要： 胰腺癌症状的及时识别是一个持续的临床挑战，常常导致晚期诊断和预后不良。 肿瘤“劫持”胰腺间质结构限制了系统化疗药物的摄取。 使用内窥镜技术的局部药物输送系统（DDS）被广泛利用，早期结果表明对肿瘤生长的控制有所改善。 需要能够整合内窥镜资源和智能材料系统的技术，以更好地控制化疗药物的时空输送。 我们展示了通过设计与电纺织物集成的无溶剂载药乙烯基苯基功能化明胶（gel4vbc）纳米颗粒（NPs）实现超声（US）触发的局部药物释放。 负载白蛋白的NPs封装在聚（乙烯醇）（PVA）涂层中的聚（ε-己内酯）织物中，表现出由调节PVA浓度（0-1 wt.%）和US强度（0-3 W/cm2）控制的可调触发NPs输送。 将负载NPs的织物固定到磁性触须机器人（MTR）上，使得在US触发释放负载NPs的白蛋白并收缩MTR之前，能够自动操纵进入仿生胰管。 白蛋白的释放通过改变负载NPs的MTR涂层织物的表面积来控制。 在此，我们设计了一种新型DDS，能够方便地集成到软体机器人中，并实现治疗载药NPs的US触发输送。 显示英文摘要

摘要： The prompt identification of pancreatic cancer symptoms is an ongoing clinical challenge, often leading to late diagnosis and poor prognosis. Tumor 'hijacking' of the pancreatic stromal structure limits the uptake of systemic chemotherapeutics. Localized drug delivery systems (DDS) using endoluminal techniques are widely utilized, with positive early results for improved control over tumor growth. There is a need for technologies that integrate endoluminal resources and intelligent material systems to better control the spatiotemporal delivery of chemotherapeutics. We demonstrate the ultrasound (US)-triggered localized release of therapeutics through the design of solvent traceless drug-loaded vinylbenzyl-functionalized gelatin (gel4vbc) nanoparticles (NPs) integrated with an electrospun fabric. Albumin-loaded NPs encapsulated into a poly(vinyl alcohol) (PVA) coating of a poly(epsilon-caprolactone) fabric evidence tunable triggered NP delivery controlled by regulating PVA concentration (0-1 wt.%) and US intensity (0-3 W/cm2). The fixation of the NP-coated fabric to a magnetic tentacle robot (MTR) enables the automated manipulation into a phantom pancreatic duct before the US-triggered release of NP-loaded albumin and MTR retraction. Albumin release is controlled by varying the surface area of the NP-loaded MTR-coating fabric. Herein we have designed a novel DDS capable of facile integration into soft robotics and US-triggered delivery of therapeutic-loaded NPs.