标题： 突触增强促进了体外培养的海马网络中的类似记忆吸引子动力学 显示英文标题

标题： Synaptic potentiation facilitates memory-like attractor dynamics in cultured in vitro hippocampal networks

摘要： 集体神经元的节奏动力学对于记忆形成等认知功能至关重要，但神经元如何自我组织以产生这种活动尚不明确。 基于吸引子的模型已被成功用作神经元网络中记忆存储的理论框架。 活动依赖的突触传递修改被认为是学习和记忆的生理基础。 本研究的目的是证明，在体外海马神经元网络上使用一种已显示可以增强突触强度的药物扰动，符合吸引子模型所理论化的动态假设。 我们使用一个细胞外电极网格来研究这种扰动后的网络活动变化，并表明处理后整体的尖峰和爆发活动有持续增加。 这种活动的增加似乎将更多的“异常”尖峰纳入爆发中。 最后，相位图表明活动模式保持不变，表明网络处于稳定的动态状态。 显示英文摘要

摘要： Collective rhythmic dynamics from neurons is vital for cognitive functions such as memory formation but how neurons self-organize to produce such activity is not well understood. Attractor-based models have been successfully implemented as a theoretical framework for memory storage in networks of neurons. Activity-dependent modification of synaptic transmission is thought to be the physiological basis of learning and memory. The goal of this study is to demonstrate that using a pharmacological perturbation on in vitro networks of hippocampal neurons that has been shown to increase synaptic strength follows the dynamical postulates theorized by attractor models. We use a grid of extracellular electrodes to study changes in network activity after this perturbation and show that there is a persistent increase in overall spiking and bursting activity after treatment. This increase in activity appears to recruit more "errant" spikes into bursts. Lastly, phase plots indicate a conserved activity pattern suggesting that the network is operating in a stable dynamical state.