标题： 决策网络中反应时间的损害作为创伤性脑损伤和神经退行性疾病诊断标志物 显示英文标题

标题： Reaction time impairments in decision-making networks as a diagnostic marker for traumatic brain injuries and neurodegenerative diseases

摘要： 弥漫性轴突肿胀（FAS）的存在是许多神经退行性疾病和创伤性脑损伤中的一个标志性细胞特征。 FAS对通过受影响神经元传播的尖峰序列编码有显著影响，导致在神经网络层面上的信号处理受损。 这项工作首次将三个研究领域结合起来：(i) 通过群体编码在兴奋性-抑制性（EI）神经网络中的信号处理，(ii) 由刺激产生的证据驱动的决策理论，以及(iii) 通过FAS的受损尖峰序列传播。 因此，我们展示了一个能够表征由细胞机制驱动的受损决策的数学架构。 计算模型还导致了一些新的预测和诊断方法，以理解损伤程度和认知缺陷，包括一个关键发现，即决策反应时间而非准确性，可指示网络层面的损伤。 结果具有多种转化意义，包括可以通过简单认知和运动测试中的反应时间来表征网络损伤的程度。 显示英文摘要

摘要： The presence of diffuse Focal Axonal Swellings (FAS) is a hallmark cellular feature in many neurodegenerative diseases and traumatic brain injury. Among other things, the FAS have a significant impact on spike-train encodings that propagate through the affected neurons, leading to compromised signal processing on a neuronal network level. This work merges, for the first time, three fields of study: (i) signal processing in excitatory-inhibitory (EI) networks of neurons via population codes, (ii) decision-making theory driven by the production of evidence from stimulus, and (iii) compromised spike-train propagation through FAS. As such, we demonstrate a mathematical architecture capable of characterizing compromised decision-making driven by cellular mechanisms. The computational model also leads to several novel predictions and diagnostics for understanding injury level and cognitive deficits, including a key finding that decision-making reaction times, rather than accuracy, are indicative of network level damage. The results have a number of translational implications, including that the level of network damage can be characterized by the reaction times in simple cognitive and motor tests.