标题： 大规模生成模型中细胞分化程序的调查揭示了再生是发育的副现象 显示英文标题

标题： Large-Scale Survey of Cell-Differentiation Programs in a Generative Model Reveals Regeneration as an Epiphenomenon of Development

摘要： 发展通过多种方式将三种基本过程——不对称细胞分裂、信号传导和基因调控——结合起来，创造出多细胞生命形式的多样化。 在这里，我们尝试使用生成模型来绘制这种多样性。 我们采样数百万种生物上可行的发展方案，使我们能够评论它们所产生的细胞分化轨迹的统计特性。 我们的结果表明，与普遍观点相反，细胞类型谱系图不太可能是树状的。 相反，它们更可能是有向无环图，多个谱系汇聚到同一个终末细胞类型。 此外，与整个身体再生是发育的副现象的假设一致，我们模型生成的大多数“生物体”都可以使用多能细胞进行再生。 生成框架是模块化和灵活的，可以适应测试关于发育一般特征的其他假设。 显示英文摘要

摘要： Development combines three basic processes asymmetric --- cell division, signaling and gene regulation --- in a multitude of ways to create an overwhelming diversity of multicellular life-forms. Here, we attempt to chart this diversity using a generative model. We sample millions of biologically feasible developmental schemes, allowing us to comment on the statistical properties of cell-differentiation trajectories they produce. Our results indicate that, in contrast to common views, cell-type lineage graphs are unlikely to be tree-like. Instead, they are more likely to be directed acyclic graphs, with multiple lineages converging on the same terminal cell-type. Additionally, in line with the hypothesis that whole body regeneration is an epiphenomenon of development, a majority of the `organism' generated by our model can regenerate using pluripotent cells. The generative framework is modular and flexible, and can be adapted to test additional hypotheses about general features of development.