标题： 蛋白质-蛋白质相互作用网络的对齐 显示英文标题

标题： Alignment of Protein-Protein Interaction Networks

摘要： PPI网络对齐旨在找到不同物种网络之间的拓扑和功能相似性。 已经提出了几种对齐方法。 这些方法中的每一种都依赖于不同的对齐方法，并在对齐过程中使用不同的生物学信息，例如网络的拓扑结构以及蛋白质之间的序列相似性，但其中较少的方法整合了蛋白质之间的功能相似性。 在此背景下，我们提出了我们的算法PPINA（蛋白质-蛋白质相互作用网络对齐器），它是NETAL算法的扩展。 后者基于蛋白质的序列、功能和网络拓扑相似性来对齐两个网络。 PPINA已在真实的PPI网络上进行了测试。 结果表明，PPINA优于其他对齐算法，并提供了具有生物学意义的结果。 显示英文摘要

摘要： PPI network alignment aims to find topological and functional similarities between networks of different species. Several alignment approaches have been proposed. Each of these approaches relies on a different alignment method and uses different biological information during the alignment process such as the topological structure of the networks and the sequence similarities between the proteins, but less of them integrate the functional similarities between proteins. In this context, we present our algorithm PPINA (Protein-Protein Interaction Network Aligner), which is an extension of the NETAL algorithm. The latter aligns two networks based on the sequence, functional and network topology similarity of the proteins. PPINA has been tested on real PPI networks. The results show that PPINA has outperformed other alignment algorithms where it provides biologically meaningful results.