标题： 基于分子动力学的衰老时钟和衰老路线图预测与日晷 显示英文标题

标题： Molecule-dynamic-based Aging Clock and Aging Roadmap Forecast with Sundial

摘要： 解决监督衰老时钟中不可避免的偏差，我们引入了Sundial，这是一种新的框架，通过扩散场建模分子动力学，捕捉种群层面的衰老过程和个体层面的相对衰老顺序。 Sundial能够无偏估计生物年龄并预测衰老路线图。 来自Sundial的快速衰老个体比来自监督衰老时钟识别的个体具有更高的疾病风险。 这个框架为探索关键主题开辟了新途径，包括年龄和性别特异的衰老动态以及更快但健康衰老路径。 显示英文摘要

摘要： Addressing the unavoidable bias inherent in supervised aging clocks, we introduce Sundial, a novel framework that models molecular dynamics through a diffusion field, capturing both the population-level aging process and the individual-level relative aging order. Sundial enables unbiasedestimation of biological age and the forecast of aging roadmap. Fasteraging individuals from Sundial exhibit a higher disease risk compared to those identified from supervised aging clocks. This framework opens new avenues for exploring key topics, including age- and sex-specific aging dynamics and faster yet healthy aging paths.