标题： 使用三尺度数学模型评估间日疟原虫森林疟疾的干预措施 显示英文标题

标题： Evaluating interventions for Plasmodium vivax forest malaria using a three-scale mathematical model

摘要： 恶性疟原虫病例在大湄公河次区域森林边缘地区的比例上升，突显了针对森林活动人群的药物和蚊媒控制技术的重要性。 为了在休眠子激活和季节性森林迁移背景下评估最佳的抗疟疾干预措施，我们扩展了一个之前开发的用于描述恶性疟传播的三尺度积分微分方程模型。 特别是，我们将该模型拟合到越南四年间的收集数据上，以深入了解当地的恶性疟动态，并验证模型捕捉流行病学趋势的能力。 校准后的模型随后被用来生成森林活动人群中大规模药物管理（MDA）的最佳时间表，并评估森林周边地区蚊媒控制技术（如长效杀虫蚊帐和室内滞留喷洒）的效果。 我们的研究结果强调了最佳MDA时间对人口统计学特征的依赖性，以及针对蚊虫叮咬率的干预措施的重要性，同时也指出了休眠子靶向抗疟药疗效的必要性。 显示英文摘要

摘要： The rising proportion of Plasmodium vivax cases concentrated in forest-fringe areas across the Greater Mekong Subregion highlights the importance of pharmaceutical and mosquito control techniques specifically targeted towards forest-going populations. To mathematically assess best-possible antimalarial interventions in the context of hypnozoite reactivation and seasonal forest migration, we extend a previously developed three-scale integro-differential equations model of P. vivax transmission. In particular, we fit the model to data gathered over a four-year period in Vietnam to gain insight into local P. vivax dynamics and validate the model's ability to capture epidemiological trends. The calibrated model is then used to generate optimal schedules for mass-drug administration (MDA) in forest-goers and gauge the efficacy of vector control techniques (such as long-lasting insecticide nets and indoor residual spraying) in forest-adjacent areas. Our results highlight the dependence of optimal MDA timing on the demographics of the human population, the importance of interventions targeting the mosquito bite rate, and the need for efficacy in hypnozoite-targeting antimalarial drugs.