标题： 从羧甲基纤维素通过一锅水热碳化合成纳米颗粒用于药物包埋研究 显示英文标题

标题： Synthesis of nanoparticles from carboxymethyl cellulose using one-pot hydrothermal carbonization for Drug Entrapment Studies

摘要： 多孔纳米材料由于其多种性能和潜在应用而最近引起了广泛关注。 在本研究中，使用羧甲基纤维素（CMC）通过一步水热碳化（HTC）合成了碳纳米颗粒（CNPs）。 尿素被用作碳化的氮源。 在碳化过程中，CMC溶液中的尿素导致纳米颗粒的直径从4微米减少到1微米。 上述样品在高温下的活化过程分别产生了直径为51纳米和31纳米的纳米颗粒。 尿素的存在及其活化产生的积极效应生成了不同的功能基团，包括C-N、N-H和C-三键-N，随着芳香环数量的增加，这可能有助于药物的捕获。 另一方面，活化的CNPsu（ACNPsu）具有最多的芳香环和最少的羟基，在其结构中碳含量为84.66%，氧含量为12.29%。 ACNPs和ACNPsu表现出I型等温线，表明它们是微孔材料，具有高比表面积，分别为552.9 m²/g和351.01 m²/g。 高比表面积是活性炭的特征，具有高的吸附能力。 因此，合成的材料使用SEM、TEM、DLS、BET、FTIR、HNMR和TGA技术进行了表征。 最后，研究了带正电荷的克林霉素药物（CD）在不同类型的带负电荷纳米颗粒中的包封，以用于生物医学工程应用中的药物输送。 显示英文摘要

摘要： Porous nanomaterials have recently attracted a lot of attention due to various properties and potential applications. In this study, carbon nanoparticles (CNPs) were synthesized by the one-pot hydrothermal carbonization (HTC) using carboxymethyl cellulose (CMC). Urea was used as the nitrogen source for carbonization. The presence of urea in CMC solution for carbonization resulted in CNPsu reduction in the diameter of particles from 4 micrometer to 1 micrometer. Activation process at high temperature for both the above samples resulted in nanoparticles with diameter of 51 nm and 31 nm, respectively. The positive effect of presence urea and its activation generated different functional groups including C-N, N-H, and C -(triple bond)- N with increasing aromatic rings that probably may help entrapment of drugs into them. On the other hand, activation CNPsu (ACNPsu) has the most aromatic rings with the lowest hydroxyl groups with 84.66% carbon and 12.29% oxygen in its structures. ACNPs, and ACNPsu exhibited a type I isotherm indicating microporous materials with a high surface area about 552.9 m2/g and 351.01 m2/g, respectively. The high surface area was characteristic of activated carbons with their high adsorption capacity. Thus, the synthesized materials were characterized using SEM, TEM, DLS, BET, FTIR, HNMR, and TGA techniques. Finally, the encapsulation of clindamycin drug (CD) with positive charge in different types of NPs with negative charge was investigated for drug delivery in biomedical engineering applications.