标题： 血液凝固的数学模型在静脉内激光治疗期间 显示英文标题

标题： Mathematical model of blood coagulation during endovenous laser therapy

摘要： 静脉内激光治疗（ELT）作为一种用于消融大浅静脉的微创手术，仍可能导致血栓性并发症。 在这方面，研究ELT过程中血栓形成的的主要模式并建立静脉内热诱导血栓形成（EHIT）的模型是相关的。 基于血液凝固过程中生化过程受扩散限制的假设，通过根据Stokes-Einstein方程重新计算反应速率，本文建立了一个简单的点模型来描述ELT期间的血液凝固。 使用该模型的结果表明，血液加热会导致凝血酶生成速率增加，其浓度峰值出现时间减少5-6倍，而其幅度几乎保持不变。 加热导致纤维蛋白团块迅速形成，并出现细胞尺寸较小的纤维蛋白-聚合物网络。 还显示了对所选流变学模型的定量依赖性。 本文提供了使用该模型所需的所有数据，以确保可重复性。 显示英文摘要

摘要： Endovenous laser therapy (ELT) as a minimally invasive procedure for ablation of large superficial veins, nevertheless, can cause complications of thrombotic nature. In this regard, the study of the main patterns of thrombus formation during ELT and modelling of endovenous heat-induced thrombosis (EHIT) is relevant. Based on the assumption of diffusion limiting of biochemical processes occurring during the coagulation of blood, by recalculating the reaction rates according to the Stokes-Einstein equation, a simple point model of blood coagulation during ELT was built in this paper. As a result of the use of this model, it was demonstrated that blood heating entails an increase in the rate of thrombin production, a decrease in the time for achieving the peak of its concentration by 5-6 times with its almost constant amplitude. Heating leads to the rapid formation of fibrin clusters and the appearance of a fibrin-polymer network with a smaller cell size. The quantitative dependence on the selected rheological model was also shown. All the data necessary for using the model are given in this article for reproducibility.