标题： 小檗碱的减肥研究进展 显示英文标题

标题： Progress of the anti-obesity of Berberine

摘要： 肥胖被定义为体内脂肪的过度积累或异常分布。 根据《世界肥胖图谱2024》的数据，肥胖患病率的增加已成为成人以及儿童和青少年的主要全球健康问题。 尽管近年来越来越多的药物已被批准用于治疗肥胖，但其中许多药物不可避免地具有副作用，这增加了对安全、可及且有效的新型肥胖药物的需求，并引发了对天然产物的兴趣。 黄连素（BBR）及其代谢物以其多种药理作用而闻名。 近期的研究重点强调了BBR的抗肥胖益处，其潜在机制也逐渐被阐明。 然而，由于口服吸收差和生物利用度低，其临床应用受到限制。 基于此，本综述总结了关于BBR及其代谢物抗肥胖作用的最新研究，包括临床试验结果的进展、潜在分子机制以及吸收和生物利用度的理解。 作为一种从植物中提取的天然化合物，BBR在管理肥胖方面具有作为替代方法的潜力。 显示英文摘要

摘要： Obesity is defined as the excessive accumulation or abnormal distribution of body fat. According to data from World Obesity Atlas 2024, the increase in prevalence of obesity has become a major worldwide health problem in adults as well as among children and adolescents. Although an increasing number of drugs have been approved for the treatment of obesity in recent years, many of these drugs have inevitable side effects which have increased the demand for new safe, accessible and effective drugs for obesity and prompt interest in natural products. Berberine (BBR) and its metabolites, known for their multiple pharmacological effects. Recent studies have emphatically highlighted the anti-obesity benefits of BBR and the underlying mechanisms have been gradually elucidated. However, its clinical application is limited by poor oral absorption and low bioavailability. Based on this, this review summarizes current research on the anti-obesity effects of BBR and its metabolites, including advancements in clinical trail results, understanding potential molecular mechanisms and absorption and bioavailability. As a natural compound derived from plants, BBR holds potential as an alternative approach for managing obesity.